药物相互作用研究在新药研发和审评决策中的应用

药物相互作用改变了剂量效应关系，可能会降低疗效或增加毒性，是临床应用中合并用药治疗时重要的考虑因素。预测具有临床意义的药物相互作用是药物研发过程中获益风险评估的重要环节。本文概述了药物研发过程中药物相互作用研究的目的和意义，体内和体外研究的主要内容；梳理分析了2020年国家药品监督管理局（National Medical Products Administration, NMPA）和美国食品药品监督管理局（Food and Drug Administration, FDA）批准上市的新药药物相互作用研究情况，旨在为我国药物研发过程中药物相互作用研究及其监管审评提供参考。     

基于IEC 60870-5-104协议的调度命令发送方法研究

对IEC 60870-5-104协议的调度命令进行了研究，提出了一种基于现有IEC 60870-5-104协议的调度命令发送新方法。此技术充分利用了IEC 60870-5-104协议的文件发送功能，通过远程终端单元（RTU）向电厂发送包含调度命令的文本文件。考虑到调度命令在电力系统和电力市场结算系统安全方面的重要性，将该方法应用在电网调度自动化 SCADA 系统中，可以实现交换数据的更高可用性。     

煤矿罗茨鼓风机的安装使用与故障分析

对罗茨鼓风机的特点、结构和工作原理进行了论述,对其安装使用与故障维修进行了归纳总结.在新型罗茨鼓风机的设计中,提出了一种由偏心孤和圆线曲线组合的三叶转子齿剖面,其在对新齿轮廓进行几何模型的基础上,提出了螺旋齿轮廓,并对啮合螺旋三叶进行了比较研究.结果 表明,新的螺旋齿轮廓可以创造更大的气流,降低鼓风机压力的峰值.     

汽油气相色谱模拟馏程的应用

介绍了用AC8612气相色谱仪对六个汽油组分馏程分析的应用情况,结果表明:该方法的重复性和准确性都较好,与D86相比,结果满足方法的再现性要求,但对于差值大于3℃的点,应定期进行修正,以使结果更准确,该方法用于炼油厂各装置汽油组分馏出口的日常质量监测分析,可以提高分析效率并减少劳动强度。     

Performance of Al2O3 particle reinforced glass-based seals in planar solid oxide fuel cells

Glass-based materials are usually considered as excellent seals for jointing adjacent components in planar solid oxide fuel cells, but the uncontrollable crystallization in the glass may cause delamination and micro-cracks in such seals. To solve this problem, Al2O3 ceramic particles were added to a BaO–CaO–Al2O3–B2O3–SiO2 glass system to reduce negative effects caused by crystalline phase on the gas tightness and the joint strength in the seals. At an operating temperature of 750 °C, the glass-based seals with 20 wt% Al2O3 addition (GA80) exhibited extremely low leakage rates (~0.002 sccm/cm under an input gas pressure of 13.6 kPa) and higher shear strength (3.31 MPa). The Al2O3 ceramic addition and the crystalline phase BaAl2Si2O8 reinforced the glass matrix. Further thermal cycle analyses indicated that leakage rates for the GA80 seals remained at around 0.0025 sccm/cm after 10 thermal cycles, which was consistent with minor microstructural change and good interface bonding. Single cell testing with of GA80 seals was performed and the results demonstrated stable electrochemical performance through 6 thermal cycles at an open circuit voltage of 1.16–1.18 V, as well as a power density above 546 mW/cm2 at a current density of 925 mA/cm2. These results showed the high thermal cycle stability of the glass/Al2O3 composite seals in intermediate temperature planar solid oxide fuel cells.     

Enhanced thermal shrinkage behavior of phenolic-derived carbon aerogel-reinforced by HNTs with superior compressive strength performance

A novel carbon/m-HNTs composite aerogel was synthesized by introducing the modified halloysite nanotubes (m-HNTs) into phenolic (PR) aerogels through chemical grafting, followed with carbonization treatment. In order to explore the best proportion of HNTs to phenolic, the micromorphology of PR/m-HNTs were investigated by SEM before carbonization, confirming 10 wt% of m-HNTs is most beneficial to the porous network of aerogels. The interaction between PR and HNTs was studied by FTIR spectra, and microstructure evolution of the target product-carbon/m-HNTs composite aerogel were illustrated by SEM and TEM techniques. SEM patterns indicated that the carbon/m-HNTs aerogels maintain a stable porous structure at 1000 °C (carbonization temperature), while a ~20 nm carbon layer was formed around m-HNTs generating an integral unit through TEM analysis. Specific surface area and pore size distribution of composite aerogels were analyzed based on mercury intrusion porosimetry and N₂ adsorption–desorption method, the obtained results stayed around 500 m²g^?1 and 1.00 cm³g^?1 (pore volume) without significant discrepancy, compared with pure aerogel, showing the uniformity of pore size. The weight loss rate (26.76%) decreased greatly compared with pure aerogel, at the same time, the best volumetric shrinkage rate was only 30.83%, contributed by the existence of HNTs supporting the neighbor structure to avoid over-shrinking. The highest compressive strength reached to 4.43 MPa, while the data of pure aerogel was only 1.52 MPa, demonstrating the excellent mechanical property of carbon/m-HNTs aerogels.     

HPLC法测定伐地昔布的有关物质

建立高效液相色谱法检测伐地昔布的有关物质.采用α-酸性糖蛋白键合硅胶的手性色谱柱,以乙腈-醋酸铵缓冲液(0.01 mol/L,pH4.0)作为流动相进行梯度洗脱,检测波长215 nm.伐地昔布与5个已知杂质均可达到基线分离,在各自浓度范围内线性关系良好,平均回收率95.13％～99.77％,RSD1.10％～1.77％,检测限0.017 9～0.060 1 μg/mL,定量限0.059 7～0.200 0 μg/mL.方法专属性强,准确度好,灵敏度高,可为伐地昔布的质量控制及后续分离提纯和帕瑞昔布的质量控制提供指导.     

装配式混凝土木混合结构体系简述

上海电气研混凝土(如皋)建筑科技有限公司——建筑工业化智能创新基地项目,采用装配式混凝土木混合结构,该结构是一种新型的建筑结构体系.其承重的部分采用混凝土结构且可在工厂进行预制,围护结构采用木材制成,可在满足使用等功能的同时降低造价、减轻自重、保护环境,具有很大的发展潜力.     

50型螺旋式钢板仓卷边设备理论分析与试验

结合已有卷边设备的生产工艺和特点,研发了国内首台50型螺旋式钢板仓卷边设备,并完成了4次样机调试试验.分析了新型卷边设备关键机构的工作原理,对下轧辊调节机构进行了力学计算分析,完成了卷边孔型设计.利用显示动力学软件数值模拟了5 mm钢板的冷弯成形(卷边)过程,分析了成形过程中的等效应力和等效塑性应变.通过4次样机调试试验,将调试结果与模拟结果对比.结果 表明,折弯5 mm钢板比折弯3 mm的钢板力载荷大很多,有必要研发新型的卷边设备;卷边设备的后3个工位的应力峰值比前3个工位大,其中工位6应力峰值最大;文中的卷边孔型设计合理;卷边过程的模拟结果与试验结果一致.